Cubase 5 looks like it's gonna be GREAT! It solves some of my biggest problems with cubase to date:
- VST3 has support for side chaining, (ie. Key inputs) so that's a killer feature for me
- Updated interface (finally)
- Built-in autotune-esque functionality
- Improved time stretch
- More built in functions (woot!) which look surprisingly good for builtins

I also have high hopes for improved rewire latency (which, until now, has been far from real time).
Anyway, I don't have a lot of time to write about it, but check it out. I'm psyched especially since I'll be getting a student discount on the order of 50% :)
Check out Cubase 5! (I guess this makes me a fanboy... damn)